Medicine

Molecular distinction to refine operative and radiotherapeutic decision-making in meningioma

.MacFeeters Hamilton Neuro-Oncology Program, Little Princess Margaret Cancer Facility, University Wellness Network and also University of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDivision of Neurosurgery, Team of Surgical Treatment, College of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehPrincess Margaret Cancer Cells Center, College Health System, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDalla Lana University of Public Health, Educational Institution of Toronto, Toronto, Ontario, CanadaOlli SaarelaNRG Oncology Stats and Data Monitoring Center, Philadelphia, , USAStephanie L. Pughu00c2 &amp u00c2 Minhee WonTemerty Institution of Medicine, Educational Institution of Toronto, Toronto, Ontario, CanadaZeel PatelNeurosurgery Specialists of Tulsa, Tulsa, OK, USAChristopher WilsonDepartment of Nerve Surgical Procedure, Keck University of Medicine of the College of Southern The Golden State, Los Angeles, CA, USAAaron Cohen-GadolDepartment of Nerve Surgical Treatment, Indiana College College of Medicine, Indianapolis, IN, USAMohamed A. ZaazoueDepartment of Orthopedic Surgical Operation, Washington College School of Medication in St. Louis, St. Louis, MO, USAMohamed A. ZaazoueGerman Cancer Cells Consortium (DKTK), DKFZ Companion Web Site Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiCluster of Quality (EXC 2180) u00e2 $ Photo Assisted and also Functionally Instructed Cyst Therapiesu00e2 $, Eberhard Karls College Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiDepartment of Neurology as well as Interdisciplinary Neuro-Oncology, Center for Neuro-Oncology, Comprehensive Cancer Cells Facility, Hertie Institute for Medical Human Brain Investigation, Eberhard Karls College Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh Tabatabai, u00c2 Sylvia C. Kurzu00c2 &amp u00c2 Paul PasslackDepartment of Neurosurgery, Center for Neuro-Oncology, Comprehensive Cancer Cells Facility, Eberhard Karls University Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyMarcos Tatagiba, u00c2 Felix Behling, u00c2 Mirjam Renovanz, u00c2 Jens Schittenhelmu00c2 &amp u00c2 Paul PasslackDepartment of Pathology, University of San Francisco, San Francisco, CA, USADamian A. Almiron BonninHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USAEric C. HollandDepartment of Human Oncology, Educational Institution of Wisconsin Hospitals as well as Clinics, Madison, WI, USATim J. KruserCentral Mind Cyst Registry of the United States, Hinsdale, IL, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanTrans Divisional Investigation Program (TDRP), Department of Cancer Cells Epidemiology as well as Genetics (DCEG), National Cancer Principle, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanCenter for Biomedical Informatics &amp Infotech (CBIIT), National Cancer Cells Principle, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanPiedmont Mind Growth Center, Piedmonth Medical Care Device, Atlanta Ga, GA, USAAndrew E. Sloanu00c2 &amp u00c2 Andrew E. SloanDepartment of Pathology, Northwestern University, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiLou &amp Jean Malnati Brain Lump Institute at the Lurie Comprehensive Cancer Center, Northwestern Educational Institution, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USASilky Chotaiu00c2 &amp u00c2 Lola B. ChamblessDepartment of Lab Medicine and also Pathobiology, College of Toronto, Toronto, Ontario, CanadaAndrew GaoDivision of Neurosurgery, University of British Columbia, Vancouver, British Columbia, CanadaAlexander D. Rebchuku00c2 &amp u00c2 Serge MakarenkoDepartment of Pathology &amp Lab Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaStephen YipDepartment of Neuropathology, Principle of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, GermanyFelix Sahm, u00c2 Felix Sahmu00c2 &amp u00c2 Andreas von DeimlingClinical Cooperation Device Neuropathology, German Cancer Proving Ground (DKFZ), Heidelberg, GermanyFelix SahmDepartment of Pathology, Leiden University Medical Center, Leiden, The NetherlandsSybren L. N. MaasDepartment of Pathology, Erasmus MC Cancer Institute, College Medical Facility Rotterdam, Rotterdam, The NetherlandsSybren L. N. MaasRadiation Medicine Course, Princess Margaret Cancer Cells Center, Toronto, Ontario, CanadaDerek S. TsangRadiation Oncology, Utah Cancer Cells Specialists, Salt Lake Metropolitan Area, UT, USAC. Leland RogersCenter for Cancer Cells Analysis, National Cancer Cells Principle, Bethesda, MD, USAKenneth AldapeMiami Neuroscience Principle, Baptist Health And Wellness, Miami, FL, USAMichael W. McDermottDepartment of Neurosurgery, Addenbrookeu00e2 $ s Health center, Cambridge, UKThomas Santariusu00c2 &amp u00c2 Daniel M. FountainDepartment of Neurosurgery, Educational Institution Hospitals Cleveland and Instance Western Reserve Educational Institution, Cleveland, OH, USAWarren SelmanDepartment of Pathology, Educational Institution Hospitals Instance Medical Center, Cleveland, OH, USAMarta CouceDepartment of Neurosurgery, Centro Hospitalar Universitu00c3 u00a1 rio S. Jou00c3 u20a4 o, Porto, PortugalBruno CarvalhoCenter for Neuro-Oncology, Dana-Farber/Brigham as well as Womenu00e2 $ s Cancer cells Facility, Boston Ma, MA, USAPatrick Y. WenDepartment of Neurosurgery, Battle Each Other College, Durham, NC, USAKyle M. WalshDepartment of Neurosurgery, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The NetherlandsEelke M. BosDepartment of Neurosurgery, Brigham and also Womenu00e2 $ s Health center, Harvard Medical Institution, Boston Ma, MA, USAWenya Linda BiDepartment of Radiology, Brigham as well as Womenu00e2 $ s Health center, Dana-Farber Cancer Institute, Harvard Medical School, Boston Ma, MA, USARaymond Y. HuangDepartment of Neurology, Department of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical College, Boston, MA, USAPriscilla K. BrastianosDepartment of Radiation Oncology, Massachusetts General Health Center, Boston, MA, USAHelen A. ShihDepartment of Neurology, Hermelin Brain Cyst Center, Henry Ford Health And Wellness, Detroit, MI, USATobias WalbertDepartment of Neurosurger, Hermelin Mind Lump Facility, Holly Ford Health And Wellness, Detroit, MI, USAIan Lee, u00c2 Ana Valeria Castro, u00c2 Houtan Noushmehru00c2 &amp u00c2 James M. SnyderDepartment of Pathology, College of Texas Medical Branch, Galveston, TX, USAMichelle M. FelicellaDepartment of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyFrancesco Dimecou00c2 &amp u00c2 Andrea SaladinoNeuropathology System, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyBianca PolloDepartment of Neurosurgery, LMU University Hospital, LMU Munich, Munich, GermanyChristian Schichoru00c2 &amp u00c2 Ju00c3 u00b6 rg-Christian TonnDepartment of Radiation Oncology, Charitu00c3 u00a9 u00e2 $ "Universitu00c3 $ tsmedizin Berlin, Corporate Participant of Freie Universitu00c3 $ t Berlin and Humboldt-Universitu00c3 $ t zu Berlin, Berlin, GermanyFelix EhretDepartment of Radiology, Mayo Center, Rochester, MN, USATimothy J. KaufmannDepartment of Lab Medication and Pathology, Mayonnaise Center, Rochester, MN, USADaniel H. Lachance, u00c2 Caterina Gianniniu00c2 &amp u00c2 Aditya RaghunathanDepartment of Oncology, Branch of Medical Oncology, Mayo Clinic, Rochester, MN, USAEvanthia GalanisDepartments of Neuro-Oncology and Neurosurgery, Moffitt Cancer Center, Tampa, FL, USAMichael A. VogelbaumNeuropathology Device, Surgical Neurology Branch, National Principle of Neurological Disorders and Stroke, National Institutes of Wellness, Bethesda, MD, USAPatrick J. CiminoDepartment of Nerve Surgical Operation, Northwestern Educational Institution, Northwestern Medicine, Chicago, IL, USAMark YoungbloodDepartment of Pathology, NYU Langone Medical Facility, Nyc, NY, USAMatija SnuderlDepartment of Radiation Oncology, NYU Langone Health, The Big Apple Educational Institution, The Big Apple, NY, USAErik P. SulmanDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma Metropolitan Area, OK, USAIan F. DunnPeninsula Schools of Medicine and also Dental Care, Plymouth University, Plymouth, UKC. Oliver HanemannDepartment of Neurosurgery, Royal College of Surgeons in Ireland, Dublin, IrelandMohsen JavadpourDepartment of Anatomical as well as Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong KongHo-Keung NgDepartment of Individual Genetics, College of California, Los Angeles, Los Angeles, CA, USAPaul C. BoutrosDepartment of Neurosurgery, University of The Golden State, Los Angeles, Los Angeles, USARichard G. EversonDepartment of Neurosurgery, Teaching Hospital of Larissa, College of Medication, University of Thessaly, Larissa, GreeceAlkiviadis Tzannisu00c2 &amp u00c2 Konstantinos N. FountasDepartment of Neurosurgery, College Medical Center Regensburg, Regensburg, GermanyNils Ole SchmidtDepartment of Surgical Procedure, Department of Neurosurgery, College of Alberta, Edmonton, Alberta, CanadaKarolyn AuCenter of Neurosurgery, Division of General Neurosurgery, Educational Institution of Perfume, Perfume, GermanyRoland GoldbrunnerDepartment of Neurology, Professors of Medicine, University Hospital Fragrance, Educational Institution of Perfume, Fragrance, GermanyNorbert GalldiksLaboratory for Neurooncology as well as Experimental Neurosurgery, Division of General Neurosurgery, Facility for Neurosurgery, Fragrance, GermanyMarco TimmerDepartment of Neurosurgery, Teaching Hospital of Copenhagen-Rigshospitalet, Copenhagen, DenmarkTiit Illimar MathiesenDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyManfred Westphal, u00c2 Katrin Lamszusu00c2 &amp u00c2 Franz L. RicklefsDepartment of Neurosurgery, Teaching Hospital Heidelberg, Heidelberg, GermanyChristel Herold-Mende, u00c2 Christine Jungku00c2 &amp u00c2 Gerhard JungwirthDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, GermanyMaximilian DengLeeds Principle of Medical Investigation at St. Jamesu00e2 $ s, University of Leeds, Leeds, UKSusan C. ShortDepartment of Neurosurgery, The Walton Facility NHS Foundation Leave, Liverpool, UKMichael D. JenkinsonInstitute of Neuropathology, Otto-Von-Guericke-University, Magdeburg, GermanyChristian MawrinDepartment of Neurosurgery, Manchester Facility for Scientific Neurosciences, Salford Royal Medical Facility NHS Foundation Leave, Salford, UKAbdurrahman I. Islimu00c2 &amp u00c2 Omar N. PathmanabanDepartment of Neurosurgery, Royal Melbourne Health Center, Melbourne, VIC, AustraliaKatharine J. Drummondu00c2 &amp u00c2 Andrew MorokoffDepartment of Radiation Oncology, University of The Golden State, San Francisco, San Francisco, CA, USADavid R. RaleighDepartment of Neurosurgery, Educational Institution of California, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Nicholas A. ButowskiDepartment of Pathology, Educational Institution of The Golden State, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Arie PerrySchool of Drug Sciences of Ribeiru00c3 u20a4 o, Preto College of Su00c3 u20a4 o Paulo, Su00c3 u20a4 o Paulo, BrazilTathiane M. MaltaDepartment of Pathology and also Laboratory Medication, University of Saskatchewan University of Medication, Saskatoon, Saskatchewan, CanadaViktor ZherebitskiyDivision of Neurosurgery, Royal Teaching Hospital, Educational Institution of Saskatchewan, Saskatoon, Saskatchewan, CanadaLuke HnennyUSC Pituitary Center, USC Radiosurgery Facility, Keck College of Medicine of USC, Los Angeles, CA, USAGabriel ZadaDepartment of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, Hamm, GermanyAntonio SantacroceNuclear Medicine and also Scientific Molecular Image Resolution, Department of Radiology, Eberhard Karls University of Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyChristian la Fougu00c3 u00a8 reDepartment of Neurosurgery, Yale University of Medicine, New Haven, CT, USAJennifer MoliternoDepartment of Neurosurgery, Tufts Medical Center, Boston, MA, USAAlper DincerArthur and also Sonia Labatt Mind Tumor Research Study Center, The Hospital for Sick Kid, Toronto, Ontario, CanadaGelareh ZadehManuscript writing, figure preparation, basic statistical study and also overall bioinformatics were actually executed through J.Z.W. Molecular classification, design building as well as bioinformatics support was delivered through V.P., A.P.L. and J.L. TERT marketer sequencing was executed through C.G. Duplicate amount variant analysis and naming were conducted through A.P.L. Molecular analyte extraction, metrology and also sequencing were actually performed by J.Z.W., A.P.L., C.G., A.A. and also Z.P. DKFZ methylation class and subdivision judgment was executed through R.Y. as well as R.K. using the publicly readily available online tool made through F.S. RNA sequencing review was actually performed by V.P. as well as J.L. Biostatistical customer review was carried out through O.S. Professional data from the NRG Oncology RTOG-0539 meningioma scenarios were provided by S.L.P. and M.W. Scientific meningioma samples and also matching scientific data were given by C.W., A.C.G., M.A.Z., G.T., M.T., F.B., D.A.A.B., E.C.H., J.B.S., A.E.S., C.H., S.C., L.B.C., A.R., S.M. as well as S.Y. Pathologic customer review was actually conducted through A.G. and also K.A. Radiotherapy records of institutional retrospective meningioma cases were actually provided by D.S.T. Research study layout and conception were performed by J.Z.W, F.N. as well as G.Z. All writers took part in composition review as well as corrections in some capability.